Is amlodipine a diuretic?

Is amlodipine a diuretic, Before you get answers to your questions about the drug amlodipine diuretic in part helps you understand in advance about the use of medicines amlodipine.

Treatment of hypertension. Can be used alone to control blood pressure in most patients. Patients uncontrolled with a single amlodipine treatment can be given in combination with amlodipine group thiazide diuretics, beta-adrenoceptor inhibitor or angiotensin converting enzyme inhibitors. Treatment of ischemia myocardial good for stable angina or variant angina. Can be used as monotherapy or in combination with anti-angina drugs more
Sufferers are sensitive to dihydropyridine.
Amlodipine is a calcium influx inhibitor (calcium ion antagonist) that inhibits the transmembrane influx of calcium ion2 into cardiac and smooth muscle. Mechanism of action of antihypertensive amanitin for direct relaxing effect on vascular smooth muscle. The exact mechanism of amlodipine to relieve angina is not entirely known, but far amlodipine total ischemia with two ways:

1. Causing dilation of peripheral arterioles so far total peripheral resistance (afterload) against the work of the heart. Because it does not cause reflex tachycardia, the energy consumption and decreases myocardial oxygen demand. This matter
can enhance the effectiveness of amlodipine against myocardial ischemia.

2. Potential dilated main coronary arteries and coronary arterioles, both in normal circumstances and ischemia. This dilatation increases myocardial oxygen delivery in patients with coronary artery spasm (Prinzmetal angina or variant angina).

After oral administration of therapeutic doses, amlodipine is well absorbed, and peak plasma levels reached 6-12 hours after administration. Achieved steady plasma levels in 7-8 days after administration once daily continuously. A total of 97.50 amlodipine in the circulation is bound to plasma proteins.

In patients with hypertension, once daily dosing provides significant blood pressure reduction is clinically well on supine / standing after the 24-hour interval. Due to the slow onset of acute hypotension does not occur after administration of amlodipine.

In patients with angina, once daily dosing increases the total exercise time and decrease the frequency of angina attacks and nitroglycerin tablet consumption. Amlodipine does not affect or change the effect of fat metabolites in the plasma.

Hypertension and Angina: Common dose is 5mg once daily, may be increased to a maximum of 7, SMG / day depending on individual patient response. Hypertension: The initial dose can be initiated with a 2.5 mg dose.

No dosage adjustment of amlodipine when administered together with thiazide diuretics, beta-blockers or angiotensin converting enrp.
Overdose: Although there are no studies that mention of overdoses amlodipine, the available data indicate that an overdose can cause excessive peripheral vasodilation with a subsequent mark in the form of systemic hypotension longer.
Clinically significant hypotension due to amlodipine overdosage requires active cardiovascular support including monitoring of cardiac and respiratory function, elevation of the limb, and attention to circulating fluid volume and urine output.

Vasoconstrictor substance can help restore vascular stress and blood pressure and is given when there is no contraindication to its use. Because amlodipine mostly protein bound, dialysis is not profitable. In some cases, lavage can help lower the absorption rate of amlodipine.

Side effects
Amlodipine is well tolerated; side effects are common are a headache, edema, fatigue, nausea, redness (flushing), and dizziness. There is no laboratory test abnormalities are clinically significant associated with amlodipine.

Warnings and cautions
Usage in patients with renal failure.
Amlodipine mostly metabolized into inactive metabolites which 10% is excreted in an entire form in the urine. Changes in plasma levels of amlodipine no correlation with the degree of renal failure. Amlodipine can be used in patients with renal impairment with healthy doses. Amlodipine can not be dialyzed.

Usage in patients with liver failure
Amlodipine half-life is longer in patients with liver failure, and dosage recommendations have not been established. Particular attention should need to use these drugs in patients with liver failure.

Pengganaan on pregnant and lactating mothers
Safe use of amlodipine in pregnant and lactating women have not been demonstrated. The use in pregnant women and breastfeeding is only recommended when there is no safer alternative and when the disease itself carries greater risks to the mother and child.

The use in children
Since there are no clinical trials in patients with the kids, amlodipine is not recommended directly.

Usage in patients with elderly
Although the possibility of older patients had higher levels of amlodipine in plasma is greater than younger patients, the same terminal elimination half-life. Amlodipine used at similar doses in patients both elderly and younger patients, is equally well tolerated; so for older patients with commonly recommended dosing.

Drug interactions
Amlodipine safely administered together thiazide diuretics, beta blockers (beta blockers), angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual nitroglycerin, drugs NSAID (non-steroidal anti-inflammatory), antibiotics and oral hypoglycemic drugs. In studies specifically mentioned that the administration of amlodipine air-alike digoxin did not change serum digoxin levels. Award along cimetidine did not alter the pharmacokinetics of amlodipine.

Is amlodipine a diuretic?
As was explained earlier that that Amlodipine is a calcium-channel blocker. It will not lower blood pressure and diuretic drugs.

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