The side effects of the use of diuretic drugs in the blood


Here are the side effects of the use of diuretic drugs in human blood:

1. Hypokalemia
Deficiency of potassium in the blood. All diuretic with a working point section distal tubule advance enlarge K and H excretion of ions as exchangeable Na ions. The result is a blood plasma potassium content falls below 3.5 mmol/liter. This situation can occur especially in heart failure treatment with high-dose furosemide, perhaps along thiazide. Symptoms of potassium deficiency are significant muscle weakness, cramps, obstipation, anorexia, sometimes also heart arrhythmia but these symptoms do not always come true. Thiazide used in hypertension with low doses (HCT and chlorthalidone 12.5 mg per day), only slightly lower potassium levels. Therefore it is not necessary disciples potassium (Slow-K 600 mg), which was once a rather frequent combination with a potassium-sparing agent has sufficient. Patients with heart rhythm disorders or are treated with digitalis should be monitored carefully, because potassium deficiency can exacerbate complaints and increase digoxin toxicity. On them also d worry about an increased risk of sudden death (sudden heart death).

2. Hyperuricaemia
As a result of the retention of uric acid (uric acid) can occur in all diuretics, except amiloride. According to estimates, this is caused by competition between diuretic with regarding its transport uric acid in the tubules. Especially chlorthalidone provide a more high risk for retention of uric acid and gout attacks in patients who are sensitive.

3. Hyperglycemia
Can occur in patients with diabetes, especially at high doses, due to the reduction of glucose metabolism since insulin secretion is suppressed. Especially leading thiazide cause this effect, the effect of oral antidiabetic weakened by it.

4. Hyperlipidemia
Mild Hyperlipidemia may occur with elevated levels of total cholesterol (also LDL and VLDL) and triglycerides. HDL cholesterol levels are considered as a protective factor for PJP derived mainly by chlorthalidone. Exceptions are indapamide which practically does not increase the lipid levels. Clinical significance of these side effects with prolonged use not clear.

5. Hyponatremia
Diuresis due to too rapid and reliable by diuretic arches, Na plasma levels can be decreased drastically with the result hyponatremia. Geejalanya form of restlessness, muscle cramps, thirst, lethargy (sleepy), also collapsed. Especially the elderly susceptible to dehydration, then you should be given a small dose of starters which gradually increased or the drug is administered periodically, e.g., 3-4 times a week. Especially on furosemide and ethacrynic alkalosis may occur (excessive alkali in the blood).

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